Integral BioSciences (IBS) is a renowned organisation that offers a plethora of Integrated Drug Discovery Services for 14 years and counting. Our clientele comprises innovation-focused biotech start-ups and small to mid-sized pharmaceutical companies throughout the world. We assist them to accomplish their drug discovery objectives within a defined timeframe and budget.
Our team of knowledgeable and experienced scientists along with the latest tools and techniques are the reasons we have become a prestigious name as a drug discovery contract research organization in India. If you are seeking a reliable drug discovery CRO, then you just need to connect with IBS once.
Drug discovery has to evolve constantly because there is a perpetual need to develop more efficient new drugs. Therefore, all the areas required to get compounds into the clinic are permanently changing.
As we offer a bouquet of chemistry and biology oriented drug discovery solutions, we are going to mention and elaborate on some of our major strengths and capabilities. Refer to the following points and you may discover one or more than one reasons for which you might be searching for a contract research organization.
Prominent Capabilities of Integral BioSciences
The major capabilities that make Integral BioSciences a well-equipped drug discovery CRO are as follows:
- Computer-AidedDrug Designing (CADD)
CADD is a modern computational technique used for drug discovery process to identify, develop and optimize a potential lead. CADD approach saves time and is cost-effective. CADD comprises computational chemistry, molecular modelling, molecular design and rational drug design.
CADD techniques are gaining popularity in drug discovery laboratories worldwide. As they are utilised in 4 distinct phases in drug discovery:
- For screening small molecule library against the target through virtual screening methods to identify leads/hits
- To investigate the specificity of the desired hits from virtual screening through molecular docking in the active site of the known targets
- To assess ADME properties of the selected hit using in silico techniques
- Optimization of leads by designing better molecules for synthesis and evaluation.
- Organic Synthesis
Organic synthesis provides opportunities to transform integrated drug discovery since it involves the creation of novel, biologically active, safe and suitably targeted molecules along with the improvement of lead compounds. Its scope also includes tackling the need to scale-up the compound quantities for safety and clinical studies.
Organic synthesis of new chemicalentities (NCEs) is considered as the rate-defining factor in drug discovery projects. Implementation of new technologies such as artificial intelligence and machine-assisted approaches have strengthened contract research organisations to accelerate the drug-discovery processes remarkably.
- Medicinal Chemistry
Medicinal chemistry plays a crucial role in drug discovery endeavours through the selection and synthesis of compounds that establish structure-activity relationships. It enables drug discovery CRO to assess efficacy and safety for preclinical animal testing.
High-throughput screening (HTS), combinatorial chemistry, and molecularly defined targets that allow structure-based drug design have further enhanced the role of medicinal chemists in drug discovery. In vitro screens for pharmacokinetic properties, the focus on synthesising drug-like compounds, and in vitro toxicity screens have become a prominent part of medicinal chemistry research at CROs.
- Analytical Chemistry
Analytical chemistry is critical for integrated drug development as it provides assurance of the quality, safety and efficacy of new drug compounds. The drug development process requires robust, accurate analytical methods to support different stages: from preclinical studies to drug formulation and clinical studies.
Molecular-biology-based analytical methods facilitated drug discovery CROs for efficient high-throughput screening of new drug candidate molecules. It comprises a multidisciplinary analytical approach from cell-based assay to sophisticated spectroscopic technologies; to accomplish the need in drug discovery from simple organic molecules to functional proteins used as candidate drugs.
- In-vitro DMPK
Drug metabolism and pharmacokinetics (DMPK) is one of the core drug discovery services that deals with the biotransformation of a drug compound and significant pharmacokinetic properties to assess drug safety. Robust In-Vitro DMPK studies are required to characterise and understand the corresponding drug profile. It evaluates several characteristics of drugs that include bioavailability, distribution volume, half-life, drug-drug interaction, and metabolic profile.
Major types and corresponding purposes of DMPK Assay are as follows:
- Assess free drug level in the body through plasma protein binding DMPK
- Determine metabolic stability in liver microsomes and other applicable biological fractions
- Evaluate drug interaction and safety through cytochrome P450 inhibition, induction, and polymorphism DMPK studies
- Assess Gut, BBB or Cellular Permeability through Caco-2, MDCK-1, or Pampa DMPK assays
Another benefit of drug metabolism and pharmacokinetics (DMPK) research during drug discovery and development is that it allows scientists at drug discovery laboratories to do reasonable structural modifications. Thus, the drug can be improved by modifying pharmacokinetic properties and efficacy.
Biochemistry holds a key/significant position in drug discovery by establishing an interface between chemistry, structural biology and cell biology. A big fraction of drug design and development projects start with a basic understanding of biochemical principles and enzyme-substrate complexes..
With such an understanding of the characteristics of amino acids and protein folding, scientists at drug discovery CRO become able to design drugs that will effectively interact with the human body. By applying various ways for drug screening such as top-down and bottom-up methods, the drug discovery teams discover new molecular entities, exploring potency and selectivity combined with structural data.
- Cell Biology
Molecular and cellular biology has remarkably improved theunderstanding of human disease and the role of cell biologists in drug discovery services & pharmacology is expanding with each passing day. Their role is significant for the earliest preclinical stages of drug development, especially in the identification and evaluation of potential drug targets.
Cell biology experts at a drug discovery contract research organization provide a wide range of cell-based drug discovery assays throughout the drug development process including drug screening and profiling services.
- Intellectual Property Services
Protection of Intellectual Property is essential for drug discovery as we can observe a constant innovation in the pharmaceutical industryregarding new medicines. Intellectual property services are prerequisite for planning, commercializing and protecting these innovations.
Biopharma companies need to make sincere efforts to manage their IP Rights. They need to extensively protect their medical innovations as IP assets by taking appropriate steps to develop an IP strategy for dealing with possible IP violations.
Get in Touch with Integral Biosciences to Outsource Your Drug Discovery Needs
Integral BioSciences is a prominent drug discovery contract research organisation enabling pharma, biotech, and consumer health partners to optimise drug development, approval and launch-related tasks. With the broad and deep scale expertise in drug development sciences, IBS has become a preferred CRO partner for outsourcing drugs discovery projects. Get in touch with expert scientists at IBS to explore more about our capabilities and utilise them.