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BIOLOGY (IN-VITRO)
BIOCHEMISTRY
- Biochemistry (Cell free assays on following platforms)
- TR-FRET (HTRF)
- Luminescence GLO (Promega)
- Enzyme Coupled assay
- Mode of inhibition studies (Competitive/Non-competitive inhibition)
CELL BIOLOGY
- Cell based assays [primary cells (mouse splenocytes & human PBMC’s) and cell lines]
- Proliferation assay / Viability / Cell death assay
- Target engagement/Mechanism of action ( Western Blotting /ELISA)
- Immuno-oncology response - Cytokine release assays in primary cells and cell lines (ELISA)
- Drug combination assay & determination of CI value (SYNERGY)
- Development and characterization of resistant cell lines (Mechanism of resistance )
ADME
In Vitro Metabolism
- Microsomal Stability
- S9 fraction Stability
- UGT Inhibition
- Cytochrome P450 Inhibition
- Metabolite Profiling and Identification
- Plasma Stability
Non-CYP mediated Metabosim
- Aldehyde Oxidase Metabolism
Protein Binding
- Plasma Protein Binding
Bio-Analysis
- BioAnalytical Method development and quantification
Solubility & Stability Studies
- Kinetic Solubility
- Thermodynamic Solubility
- pH dependent Solubility
- Solubility in Simulated Fluids
- Formulation Stability Studies
- LogD measurements