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    Our teams, facility and working environment are geared towards making the innovation faster, efficient and successful.

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    As a drug discovery CRO, IBS is armed with experience, scientific tools, computer aided drug designing, expertise in chemistry, analytical instrumentation, in-vitro pharmacology and ADME.

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    Dedicated teams include the best and brightest talent trained at Indian/International elite universities for which achieving the scientific goals is the sole priority.

BIOLOGY (IN-VITRO)

BIOCHEMISTRY
  • Biochemistry (Cell free assays on following platforms)
    • TR-FRET (HTRF)
    • Luminescence GLO (Promega)
    • Enzyme Coupled assay
    • Mode of inhibition studies (Competitive/Non-competitive inhibition)
CELL BIOLOGY
  • Cell based assays [primary cells (mouse splenocytes & human PBMC’s) and cell lines]
    • Proliferation assay / Viability / Cell death assay
    • Target engagement/Mechanism of action ( Western Blotting /ELISA)
    • Immuno-oncology response - Cytokine release assays in primary cells and cell lines (ELISA)
    • Drug combination assay & determination of CI value (SYNERGY)
    • Development and characterization of resistant cell lines (Mechanism of resistance )

 

ADME
In Vitro Metabolism
  • Microsomal Stability
  • S9 fraction Stability
  • UGT Inhibition
  • Cytochrome P450 Inhibition
  • Metabolite Profiling and Identification
  • Plasma Stability
Non-CYP mediated Metabosim
  • Aldehyde Oxidase Metabolism
Protein Binding
  • Plasma Protein Binding
Bio-Analysis
  • BioAnalytical Method development and quantification
Solubility & Stability Studies
  • Kinetic Solubility
  • Thermodynamic Solubility
  • pH dependent Solubility
  • Solubility in Simulated Fluids
  • Formulation Stability Studies
  • LogD measurements